A Hollow-Core, Magnetic, and Mesoporous Double-Shell Nanostructure: In Situ Decomposition/Reduction Synthesis, Bioimaging, and Drug-Delivery Properties

Authors

  • Huixia Wu,

    1. State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai 200050, PR China
    2. Department of Chemistry, Shanghai Normal University, Shanghai 200234, PR China
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  • Shengjian Zhang,

    1. Department of Radiology, Shanghai Cancer Hospital, Fudan University, Shanghai 200032, PR China
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  • Jiamin Zhang,

    1. Shanghai (Red Cross) Blood Center, Shanghai Institute of Blood Transfusion, Shanghai 200051, PR China
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  • Gang Liu,

    1. Department of Chemistry, Shanghai Normal University, Shanghai 200234, PR China
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  • Jianlin Shi,

    Corresponding author
    1. State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai 200050, PR China
    • State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai 200050, PR China.
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  • Lingxia Zhang,

    1. State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai 200050, PR China
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  • Xiangzhi Cui,

    1. State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai 200050, PR China
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  • Meiling Ruan,

    1. State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai 200050, PR China
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  • Qianjun He,

    1. State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai 200050, PR China
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  • Wenbo Bu

    1. State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai 200050, PR China
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Abstract

A novel in situ decomposition/reduction approach is developed to manu­facture hollow core, magnetic, and mesoporous double-shell nanostructures (HMMNSs) via in situ decomposition and reduction of a β-FeOOH nanorod core and organosilicate-incorporated silica-shell precursor. The formed HMMNSs are then aminated by silanization for further covalent conjugation to rhodamine B isothiocyanate (RBITC) and poly(ethylene glycol) (PEG) chains. The resultant RBITC-grafted and PEGylated nanocomposites (HMMNS–R/Ps) have excellent blood compatibility and very low cytotoxicity towards HeLa and MCF-7 cells, and can be taken up by cancer cells effectively in a dose-dependent manner, as confirmed by in vitro flow cytometry, confocal luminescence imaging, and magnetic resonance imaging (MRI) studies. In vivo MRI studies coupled with Prussian blue staining of slides from different organs show that the nanocomposites preferentially accumulate in liver and spleen after intravenous injection, which suggests a potential application of the nanocomposites as MRI contrast agents. Importantly, the HMMNS–R/P nanocomposites show high loading capacity for water-insoluble anticancer drugs (docetaxel or camptothecin) owing to the presence of a large inner cavity and enhanced surface area and pore volume. Furthermore, the drug-loaded nanocomposites exhibit greater cytotoxicity than the corresponding free drugs. These results confirm that the HMMNS–R/P nanocomposites are promising candidates for simultaneous bioimaging and drug delivery.

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