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CCVD Synthesis of Carbon-Encapsulated Cobalt Nanoparticles for Biomedical Applications

Authors

  • Petar Lukanov,

    1. Université de Toulouse, UPS, INP, Institut Carnot Cirimat, 118, route de Narbonne, F- 31062 Toulouse, France CNRS, Institut Carnot Cirimat, F-31062 Toulouse, France
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  • Vijay K. Anuganti,

    1. SupraMolecular Chemistry and Technology, MESA+ Institute for Nanotechnology, University of Twente, 7500 AE Enschede, The Netherlands
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  • Yulia Krupskaya,

    1. Leibniz Institute for Solid State and Materials Research - IFW Dresden, Helmholtzstraße 20, 01069 Dresden, Germany
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  • Anne-Marie Galibert,

    1. Université de Toulouse, UPS, INP, Institut Carnot Cirimat, 118, route de Narbonne, F- 31062 Toulouse, France CNRS, Institut Carnot Cirimat, F-31062 Toulouse, France
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  • Brigitte Soula,

    1. Université de Toulouse, UPS, INP, Institut Carnot Cirimat, 118, route de Narbonne, F- 31062 Toulouse, France CNRS, Institut Carnot Cirimat, F-31062 Toulouse, France
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  • Carmen Tilmaciu,

    1. Université de Toulouse, UPS, INP, Institut Carnot Cirimat, 118, route de Narbonne, F- 31062 Toulouse, France CNRS, Institut Carnot Cirimat, F-31062 Toulouse, France
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  • Aldrik H. Velders,

    1. SupraMolecular Chemistry and Technology, MESA+ Institute for Nanotechnology, University of Twente, 7500 AE Enschede, The Netherlands
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  • Ruediger Klingeler,

    1. Kirchhoff Institute for Physics, Heidelberg University, INF 227, 69120 Heidelberg, Germany
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  • Bernd Büchner,

    1. Leibniz Institute for Solid State and Materials Research - IFW Dresden, Helmholtzstraße 20, 01069 Dresden, Germany
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  • Emmanuel Flahaut

    Corresponding author
    1. Université de Toulouse, UPS, INP, Institut Carnot Cirimat, 118, route de Narbonne, F- 31062 Toulouse, France CNRS, Institut Carnot Cirimat, F-31062 Toulouse, France
    • Université de Toulouse, UPS, INP, Institut Carnot Cirimat, 118, route de Narbonne, F- 31062 Toulouse, France CNRS, Institut Carnot Cirimat, F-31062 Toulouse, France.
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Abstract

Carbon-encapsulated ferromagnetic Cobalt nanoparticles (Co@C) have been synthesized by catalytic chemical vapour deposition (CCVD). The nanoparticles, mainly ranging between 10 and 15 nm, are tightly encapsulated by 2–3 concentric graphitic carbon shells and protected from oxidation. Because of their magnetic properties (saturation magnetization of 106 emu/g and a coercivity HC of 250 Oe), Co@C nanoparticles have been investigated for hyperthermia application. Although the observed values of the specific absorption rate (28.7 W/gCo@C at 30 kA/m and 215.4 W/gCo@C at 70 kA/m) are slightly lower than required in actual hyperthermia therapies, the observed strong heating effect provides a very promising starting point for future clinical application. It is also demonstrated that these nanoparticles can at the same time be used for magnetic resonance imaging (MRI) with an efficiency comparable to commercially available T2 contrast agents.

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