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Polymer-Based Nitric Oxide Therapies: Recent Insights for Biomedical Applications

Authors

  • Michele C. Jen,

    1. M.S. Biomedical Engineering Department, Northwestern University, Evanston IL, 60208, USA
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  • María C. Serrano,

    1. Ph.D. Instituto de Ciencia de Materiales de Madrid, Consejo Superior de Investigaciones Científicas Cantoblanco, Madrid 28049, Spain
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  • Robert van Lith,

    1. M.S. Biomedical Engineering Department, Northwestern University, Evanston IL, 60208, USA
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  • Guillermo A. Ameer

    Corresponding author
    1. Sc.D. Biomedical Engineering Department, Northwestern University, Evanston IL, 60208, USA, Chemistry of Life Processes Institute, Evanston IL, 60208, USA, Institute for BioNanotechnology in Medicine, Northwestern University, Chicago IL, 60611, USA and Division of Vascular Surgery, Feinberg School of Medicine, Northwestern University, Chicago IL, 60611, USA
    • Sc.D. Biomedical Engineering Department, Northwestern University, Evanston IL, 60208, USA, Chemistry of Life Processes Institute, Evanston IL, 60208, USA, Institute for BioNanotechnology in Medicine, Northwestern University, Chicago IL, 60611, USA and Division of Vascular Surgery, Feinberg School of Medicine, Northwestern University, Chicago IL, 60611, USA.
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Abstract

Since the discovery of nitric oxide (NO) in the 1980s, this cellular messenger has been shown to participate in diverse biological processes such as cardiovascular homeostasis, immune response, wound healing, bone metabolism, and neurotransmission. Its beneficial effects have prompted increased research in the past two decades, with a focus on the development of materials that can locally release NO. However, significant limitations arise when applying these materials to biomedical applications. This Feature Article focuses on the development of NO-releasing and NO-generating polymeric materials (2006–2011) with emphasis on recent in vivo applications. Results are compared and discussed in terms of NO dose, release kinetics, and biological effects, in order to provide a foundation to design and evaluate new NO therapies.

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