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Luminescence of Nanodiamond Driven by Atomic Functionalization: Towards Novel Detection Principles

Authors

  • Vladimíra Petráková,

    Corresponding author
    1. Czech Technical University in Prague, Faculty of Biomedical Engineering, Sítná sq. 3105, 272 01 Kladno, Czech Republic
    • Vladimíra Petráková, Czech Technical University in Prague, Faculty of Biomedical Engineering, Sítná sq. 3105, 272 01 Kladno, Czech Republic

      Miloš Nesládek, IMOMEC division, IMEC, Institute for Materials Research, University Hasselt, Wetenschapspark 1, B-3590 Diepenbeek, Belgium.

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  • Andrew Taylor,

    1. Institute of Physics, Academy of Sciences of the Czech Republic, v.v.i, Prague 8, Czech Republic
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  • Irena Kratochvílová,

    1. Institute of Physics, Academy of Sciences of the Czech Republic, v.v.i, Prague 8, Czech Republic
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  • František Fendrych,

    1. Institute of Physics, Academy of Sciences of the Czech Republic, v.v.i, Prague 8, Czech Republic
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  • Jiří Vacík,

    1. Nuclear Physics Institute, Academy of Sciences of the Czech Republic, v.v.i, 250 68 Rez near Prague, Czech Republic
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  • Jan Kučka,

    1. Nuclear Physics Institute, Academy of Sciences of the Czech Republic, v.v.i, 250 68 Rez near Prague, Czech Republic
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  • Jan Štursa,

    1. Nuclear Physics Institute, Academy of Sciences of the Czech Republic, v.v.i, 250 68 Rez near Prague, Czech Republic
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  • Petr Cígler,

    1. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Flemingovo n. 2, 166 10 Prague 6, Czech Republic
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  • Miroslav Ledvina,

    1. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Flemingovo n. 2, 166 10 Prague 6, Czech Republic
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  • Anna Fišerová,

    1. Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i., 142 20 Prague 4, Czech Republic
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  • Peter Kneppo,

    1. Czech Technical University in Prague, Faculty of Biomedical Engineering, Sítná sq. 3105, 272 01 Kladno, Czech Republic
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  • Miloš Nesládek

    Corresponding author
    1. IMOMEC division, IMEC, Institute for Materials Research, University Hasselt, Wetenschapspark 1, B-3590 Diepenbeek, Belgium
    • Vladimíra Petráková, Czech Technical University in Prague, Faculty of Biomedical Engineering, Sítná sq. 3105, 272 01 Kladno, Czech Republic

      Miloš Nesládek, IMOMEC division, IMEC, Institute for Materials Research, University Hasselt, Wetenschapspark 1, B-3590 Diepenbeek, Belgium.

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Abstract

High biocompatibility, variable size ranging from ≈5 nm, stable luminescence from its color centers, and simple carbon chemistry for biomolecule grafting make nanodiamond (ND) particles an attractive alternative to molecular dyes for drug-delivery. A novel method is presented that can be used for remote monitoring of chemical processes in biological environments based on color changes from photoluminescent (PL) nitrogen-vacancy (NV) centers in ND. The NV luminescence is driven chemically by alternating the surface chemical potential by interacting atoms and molecules with the diamond surface. Due to the small ND size, the changes of the surface chemical potential modify the electric field profile at the diamond surfaces (i.e., band bending) and intermingle with the electronic NV states. This leads to changes in NV/NV° PL ratio and allows construction of optical chemo-biosensors operating in cells, with PL visible in classical confocal microscopes. This phenomenon is demonstrated on single crystal diamond containing engineered NV centers and on oxidized and hydrogenated ND in liquid physiological buffers for variously sized ND particles. Hydrogenation of NDs leads to quenching of luminescence related to negatively charged (NV) centers and as a result produces color shifts from NV (638 nm) to neutral NV° (575 nm) luminescence. How the reduction of diamond size increases the magnitude of the NV color shift phenomena is modeled.

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