Functional Polysaccharide Composite Nanoparticles from Cellulose Acetate and Potential Applications

Authors

  • Martin R. Kulterer,

    Corresponding author
    1. Institute of Chemistry and CePoL, Karl-Franzens University Graz, Nawi Graz, Heinrichstraße 28, AT-8010 Graz, Austria
    • Institute of Chemistry and CePoL, Karl-Franzens University Graz, Nawi Graz, Heinrichstraße 28, AT-8010 Graz, Austria.
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  • Victoria E. Reichel,

    1. Institute of Chemistry and CePoL, Karl-Franzens University Graz, Nawi Graz, Heinrichstraße 28, AT-8010 Graz, Austria
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  • Rupert Kargl,

    1. Institute of Chemistry and CePoL, Karl-Franzens University Graz, Nawi Graz, Heinrichstraße 28, AT-8010 Graz, Austria
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  • Stefan Köstler,

    1. Joanneum Research, Materials, Steyrergasse 17, AT-8010 Graz, Austria
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  • Velina Sarbova,

    1. Institute of Organic Chemistry and Macromolecular Chemistry, Kompetenzzentrum Polysaccharidforschung, Friedrich Schiller University of Jena, Humboldstrasse 10, D-07743 Jena, Germany
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  • Thomas Heinze,

    1. Institute of Organic Chemistry and Macromolecular Chemistry, Kompetenzzentrum Polysaccharidforschung, Friedrich Schiller University of Jena, Humboldstrasse 10, D-07743 Jena, Germany
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  • Karin Stana-Kleinschek,

    1. Laboratory for Characterization and Processing of Polymers, University of Maribor, Smetanova Ulica 17, SI-2000 Maribor, Slovenia
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  • Volker Ribitsch

    Corresponding author
    1. Institute of Chemistry and CePoL, Karl-Franzens University Graz, Nawi Graz, Heinrichstraße 28, AT-8010 Graz, Austria
    • Institute of Chemistry and CePoL, Karl-Franzens University Graz, Nawi Graz, Heinrichstraße 28, AT-8010 Graz, Austria.
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Abstract

An in situ technique for preparing composite nanoparticles from hydrophobic cellulose acetate and hydrophilic polysaccharides using nanoprecipitation is presented. This technique allows the nanoparticles’ surface properties to be tuned very specifically. Spherical, narrow-size-distributed composite nanoparticles of different size, charge, functionality, and increased stability can be generated by using hydroxyethyl cellulose, carboxymethyl cellulose, low molecular weight chitosan, and amino cellulose. The influence of the pH and hydrophilic polysaccharide content in the particle formation is shown. The pH- and ionic strength- effective zeta-potential functions are evidence of the presence of functional polysaccharides at the nanoparticle surface. The in situ technique is compared with the adsorption of hydrophilic polysaccharides onto cellulose acetate nanoparticles in two steps. The great potential of in situ prepared composite nanoparticles in the pharmaceutical industry and bio- or food technology, as carriers of hydrophobic substances in aqueous media and for specific surface modifications, e.g., to selectively introduce strong antimicrobial properties, is illustrated.

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