Biomimetic Structures: Biomimetic Structures: Biological Implications of Dipeptide-Substituted Polyphosphazene–Polyester Blend Nanofiber Matrices for Load-Bearing Bone Regeneration (Adv. Funct. Mater. 14/2011)

Authors

  • Meng Deng,

    1. Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030, USA, Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, 06030, USA, Department of Chemical, Materials and Biomolecular Engineering, University of Connecticut, Storrs, CT, 06269, USA
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  • Sangamesh G. Kumbar,

    1. Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030, USA, Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, 06030, USA, Department of Chemical, Materials and Biomolecular Engineering, University of Connecticut, Storrs, CT, 06269, USA
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  • Lakshmi S. Nair,

    1. Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030, USA, Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, 06030, USA, Department of Chemical, Materials and Biomolecular Engineering, University of Connecticut, Storrs, CT, 06269, USA
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  • Arlin L. Weikel,

    1. Department of Chemistry, The Pennsylvania State University, University Park, PA, 16802, USA
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  • Harry R. Allcock,

    1. Department of Chemistry, The Pennsylvania State University, University Park, PA, 16802, USA
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  • Cato T. Laurencin

    Corresponding author
    1. Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030, USA, Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, 06030, USA, Department of Chemical, Materials and Biomolecular Engineering, University of Connecticut, Storrs, CT, 06269, USA
    • Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030, USA, Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, 06030, USA, Department of Chemical, Materials and Biomolecular Engineering, University of Connecticut, Storrs, CT, 06269, USA.
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Abstract

original image

Successful bone regeneration benefits from 3D bioresorbable scaffolds that mimic the hierarchical architecture and mechanical characteristics of the native tissue extracellular matrix. On page 2641, Cato T. Laurencin and co-workers present a new biomimetic scaffold design composed of electrospun polymeric nanofibers that combines unique material chemistry, hierarchical architecture, and mechanics suitable for load-bearing bone regeneration. This study, for the first time, demonstrates the feasibility of developing a mechanically competent nanofiber matrix via a biomimetic strategy.

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