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Keywords:

  • polyphosphazenes;
  • biomimetic materials;
  • composite materials;
  • nanofibers;
  • tissue engineering
Thumbnail image of graphical abstract

Successful bone regeneration benefits from 3D bioresorbable scaffolds that mimic the hierarchical architecture and mechanical characteristics of the native tissue extracellular matrix. On page 2641, Cato T. Laurencin and co-workers present a new biomimetic scaffold design composed of electrospun polymeric nanofibers that combines unique material chemistry, hierarchical architecture, and mechanics suitable for load-bearing bone regeneration. This study, for the first time, demonstrates the feasibility of developing a mechanically competent nanofiber matrix via a biomimetic strategy.