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Keywords:

  • microcontact printing;
  • tissue engineering;
  • surface modification;
  • ECM proteins;
  • patterns
Thumbnail image of graphical abstract

On page 4079, Jian-Tao Zhang, Oliver Pullig, Klaus D. Jandt, and coworkers use a facile approach, microcontact printing, to fabricate stable extracellular matrix (ECM) protein microstructures on the surfaces of implant materials. These protein structures are highly stable due to an intermediate polymer layer between the ECM proteins and the materials. Interestingly, these structures can guide the adhesion, proliferation, and organization of osteoblast-like cells. The cell morphology and alignment are controllable by the protein patterns.