Tissue Engineering: Stable Extracellular Matrix Protein Patterns Guide the Orientation of Osteoblast-like Cells (Adv. Funct. Mater. 21/2011)

Authors

  • Jian-Tao Zhang,

    Corresponding author
    1. Institute of Materials Science and Technology (IMT), Friedrich-Schiller-University Jena, Löbdergraben 32, D-07743 Jena, Germany
    • Institute of Materials Science and Technology (IMT), Friedrich-Schiller-University Jena, Löbdergraben 32, D-07743 Jena, Germany
    Search for more papers by this author
  • Juequan Nie,

    1. Institute of Materials Science and Technology (IMT), Friedrich-Schiller-University Jena, Löbdergraben 32, D-07743 Jena, Germany
    Search for more papers by this author
  • Mike Mühlstädt,

    1. Institute of Materials Science and Technology (IMT), Friedrich-Schiller-University Jena, Löbdergraben 32, D-07743 Jena, Germany
    Search for more papers by this author
  • Hilary Gallagher,

    1. Institute of Materials Science and Technology (IMT), Friedrich-Schiller-University Jena, Löbdergraben 32, D-07743 Jena, Germany
    Search for more papers by this author
  • Oliver Pullig,

    Corresponding author
    1. University of Würzburg, Orthopedic Center for Musculoskeletal Research, König-Ludwig-Haus, Brettreichstr. 11, D-97070 Würzburg, Germany
    • University of Würzburg, Orthopedic Center for Musculoskeletal Research, König-Ludwig-Haus, Brettreichstr. 11, D-97070 Würzburg, Germany.
    Search for more papers by this author
  • Klaus D. Jandt

    Corresponding author
    1. Institute of Materials Science and Technology (IMT), Friedrich-Schiller-University Jena, Löbdergraben 32, D-07743 Jena, Germany
    • Institute of Materials Science and Technology (IMT), Friedrich-Schiller-University Jena, Löbdergraben 32, D-07743 Jena, Germany
    Search for more papers by this author

Abstract

original image

On page 4079, Jian-Tao Zhang, Oliver Pullig, Klaus D. Jandt, and coworkers use a facile approach, microcontact printing, to fabricate stable extracellular matrix (ECM) protein microstructures on the surfaces of implant materials. These protein structures are highly stable due to an intermediate polymer layer between the ECM proteins and the materials. Interestingly, these structures can guide the adhesion, proliferation, and organization of osteoblast-like cells. The cell morphology and alignment are controllable by the protein patterns.

Ancillary