Get access

Up-Conversion Luminescent and Porous NaYF4:Yb3+, Er3+@SiO2 Nanocomposite Fibers for Anti-Cancer Drug Delivery and Cell Imaging

Authors

  • Zhiyao Hou,

    1. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
    2. Key Laboratory of Superlight Materials and surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China
    Search for more papers by this author
  • Chunxia Li,

    1. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
    Search for more papers by this author
  • Ping'an Ma,

    Corresponding author
    1. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
    • State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.
    Search for more papers by this author
  • Ziyong Cheng,

    1. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
    Search for more papers by this author
  • Xuejiao Li,

    1. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
    Search for more papers by this author
  • Xiao Zhang,

    1. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
    Search for more papers by this author
  • Yunlu Dai,

    1. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
    Search for more papers by this author
  • Dongmei Yang,

    1. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
    Search for more papers by this author
  • Hongzhou Lian,

    1. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
    Search for more papers by this author
  • Jun Lin

    Corresponding author
    1. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
    • State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.
    Search for more papers by this author

Abstract

Up-conversion (UC) luminescent and porous NaYF4:Yb3+, Er3+@SiO2 nanocomposite fibers are prepared by electrospinning process. The biocompatibility test on L929 fibrolast cells reveals low cytotoxicity of the fibers. The obtained fibers can be used as anti-cancer drug delivery host carriers for investigation of the drug storage/release properties. Doxorubicin hydrochloride (DOX), a typical anticancer drug, is introduced into NaYF4:Yb3+, Er3+@SiO2 nanocomposite fibers (denoted as DOX-NaYF4:Yb3+, Er3+@SiO2). The release properties of the drug carrier system are examined and the in vitro cytotoxicity and cell uptake behavior of these NaYF4:Yb3+, Er3+@SiO2 for HeLa cells are evaluated. The release of DOX from NaYF4:Yb3+, Er3+@SiO2 exhibits sustained, pH-sensitive release patterns and the DOX-NaYF4:Yb3+, Er3+@SiO2 show similar cytotoxicity as the free DOX on HeLa cells. Confocal microscopy observations show that the composites can be effectively taken up by HeLa cells. Furthermore, the fibers show near-infrared UC luminescence and are successfully applied in bioimaging of HeLa cells. The results indicate the promise of using NaYF4:Yb3+, Er3+@SiO2 nanocomposite fibers as multi-functional drug carriers for drug delivery and cell imaging.

Get access to the full text of this article

Ancillary