Superparamagnetic Nanostructures for Off-Resonance Magnetic Resonance Spectroscopic Imaging

Authors

  • Eugene Shi Guang Choo,

    1. Department of Materials Science & Engineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, 117574, Singapore
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  • Erwin Peng,

    1. Department of Materials Science & Engineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, 117574, Singapore
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  • Reshmi Rajendran,

    1. Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis Way, #02-02, 138667, Singapore
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  • Prashant Chandrasekharan,

    1. Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis Way, #02-02, 138667, Singapore
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  • Chang-Tong Yang,

    1. Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis Way, #02-02, 138667, Singapore
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  • Jun Ding,

    1. Department of Materials Science & Engineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, 117574, Singapore
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  • Kai-Hsiang Chuang,

    Corresponding author
    1. Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis Way, #02-02, 138667, Singapore
    • Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis Way, #02-02, 138667, Singapore.
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  • Junmin Xue

    Corresponding author
    1. Department of Materials Science & Engineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, 117574, Singapore
    • Department of Materials Science & Engineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, 117574, Singapore
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Abstract

This study proposes a new method to generate positive contrast in magnetic resonance imaging (MRI) using superparamagnetic contrast agents. Superparamagnetic nanostructures consisting of octahedron manganese ferrite nanoparticles embedded in spherical nanogels are fabricated using a bottom-up approach. The composite nanoparticles are strongly magnetized in an external magnetic field and produce a unique NMR frequency shift in water protons, which can be demonstrated in MR spectroscopy and imaging to be different from the bulk pool. Moreover, the particles exhibit excellent colloidal stability in aqueous media and good cell biocompatibility. Hence, these particles are potentially useful as biomarkers by taking advantage of the positive contrast effects produced in MRI.

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