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Nanostructuring Platinum Nanoparticles on Multilayered Graphene Petal Nanosheets for Electrochemical Biosensing

Authors

  • Jonathan C. Claussen,

    1. Birck Nanotechnology Center, Department of Agricultural and Biological Engineering, Purdue University, USA
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  • Anurag Kumar,

    1. Birck Nanotechnology Center, Department of Mechanical Engineering, Purdue University, 1205 W. State St., West Lafayette, IN 47907-2057 USA
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  • David B. Jaroch,

    1. Birck Nanotechnology Center, Weldon School of Biomedical Engineering, Purdue University, USA
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  • M. Haseeb Khawaja,

    1. Birck Nanotechnology Center, Department of Mechanical Engineering, Purdue University, 1205 W. State St., West Lafayette, IN 47907-2057 USA
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  • Allison B. Hibbard,

    1. Birck Nanotechnology Center, Department of Mechanical Engineering, Purdue University, 1205 W. State St., West Lafayette, IN 47907-2057 USA
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  • D. Marshall Porterfield,

    1. Birck Nanotechnology Center, Department of Agricultural and Biological Engineering, Purdue University, USA
    2. Birck Nanotechnology Center, Weldon School of Biomedical Engineering, Purdue University, USA
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  • Timothy S. Fisher

    Corresponding author
    1. Birck Nanotechnology Center, Department of Mechanical Engineering, Purdue University, 1205 W. State St., West Lafayette, IN 47907-2057 USA
    • Birck Nanotechnology Center, Department of Mechanical Engineering, Purdue University, 1205 W. State St., West Lafayette, IN 47907-2057 USA.
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Abstract

Hybridization of nanoscale metals and carbon nanotubes into composite nanomaterials has produced some of the best-performing sensors to date. The challenge remains to develop scalable nanofabrication methods that are amenable to the development of sensors with broad sensing ranges. A scalable nanostructured biosensor based on multilayered graphene petal nanosheets (MGPNs), Pt nanoparticles, and a biorecognition element (glucose oxidase) is presented. The combination of zero-dimensional nanoparticles on a two-dimensional support that is arrayed in the third dimension creates a sensor platform with exceptional characteristics. The versatility of the biosensor platform is demonstrated by altering biosensor performance (i.e., sensitivity, detection limit, and linear sensing range) through changing the size, density, and morphology of electrodeposited Pt nanoparticles on the MGPNs. This work enables a robust sensor design that demonstrates exceptional performance with enhanced glucose sensitivity (0.3 µM detection limit, 0.01–50 mM linear sensing range), a long stable shelf-life (>1 month), and a high selectivity over electroactive, interfering species commonly found in human serum samples.

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