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Vesicular Structures Self-Assembled from Oligonucleotide-Polymer Hybrids: Mechanical Prevention of Bacterial Colonization Upon their Surface Tethering Through Hybridization
Article first published online: 20 JUL 2012
DOI: 10.1002/adfm.201200988
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
1616-3028/asset/cover.gif?v=1&s=aa0e18d3cb78e9b2ca8405559bd0b600d037e2d3 "Advanced Functional Materials")
Additional Information
How to Cite
Cottenye, N., Anselme, K., Ploux, L. and Vebert-Nardin, C. (2012), Vesicular Structures Self-Assembled from Oligonucleotide-Polymer Hybrids: Mechanical Prevention of Bacterial Colonization Upon their Surface Tethering Through Hybridization. Adv. Funct. Mater., 22: 4891–4898. doi: 10.1002/adfm.201200988
Publication History
- Issue published online: 3 DEC 2012
- Article first published online: 20 JUL 2012
- Manuscript Revised: 2 JUN 2012
- Manuscript Received: 6 APR 2012
Keywords:
- block-copolymers;
- hybrid materials;
- surface modification;
- functional coatings;
- biomedical applications
Abstract
In order to design soft coatings, surface tethering of vesicular structures self-assembled from oligonucleotide-polymer hybrids is achieved through hybridization. Watson-Crick base-pairing occurs between the nucleotide sequences involved in the self-assembly and their surface-tethered complementary sequences. Combining the quartz crystal microbalance and in situ observations using confocal laser scanning microscopy, it is evidenced that the vesicles retain their morphology even under flow stress. Surprisingly, these soft surfaces prevent bacterial colonization.