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Gold Nanoshell Nanomicelles for Potential Magnetic Resonance Imaging, Light-Triggered Drug Release, and Photothermal Therapy

  1. Yan Ma1,
  2. Xiaolong Liang2,
  3. Sheng Tong3,
  4. Gang Bao3,
  5. Qiushi Ren2,
  6. Zhifei Dai1,2,*

Article first published online: 27 SEP 2012

DOI: 10.1002/adfm.201201663

Issue

Advanced Functional Materials

Advanced Functional Materials

Volume 23, Issue 7, pages 815–822, February 18, 2013

Additional Information

How to Cite

Ma, Y., Liang, X., Tong, S., Bao, G., Ren, Q. and Dai, Z. (2013), Gold Nanoshell Nanomicelles for Potential Magnetic Resonance Imaging, Light-Triggered Drug Release, and Photothermal Therapy. Adv. Funct. Mater., 23: 815–822. doi: 10.1002/adfm.201201663

Author Information

  1. 1

    Nanomedicine and Biosensor Laboratory, School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, China

  2. 2

    Department of Biomedical Engneering, College of Engineering, Peking University, Beijing 100871, China

  3. 3

    Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA

*Nanomedicine and Biosensor Laboratory, School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, China.

Publication History

  1. Issue published online: 11 FEB 2013
  2. Article first published online: 27 SEP 2012
  3. Manuscript Revised: 16 AUG 2012
  4. Manuscript Received: 19 JUN 2012

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Keywords:

  • gold nanoshells;
  • photothermal effect;
  • triggered release;
  • combined therapy;
  • nanomicelles

Abstract

A novel multifunctional drug-delivery platform is developed based on cholesteryl succinyl silane (CSS) nanomicelles loaded with doxorubicin, Fe3O4 magnetic nanoparticles, and gold nanoshells (CDF-Au-shell nanomicelles) to combine magnetic resonance (MR) imaging, magnetic-targeted drug delivery, light-triggered drug release, and photothermal therapy. The nanomicelles show improved drug-encapsulation efficiency and loading level, and a good response to magnetic fields, even after the formation of the gold nanoshell. An enhancement for T2-weighted MR imaging is observed for the CDF-Au-shell nanomicelles. These nanomicelles display surface plasmon absorbance in the near-infrared (NIR) region, thus exhibiting an NIR (808 nm)-induced temperature elevation and an NIR light-triggered and stepwise release behavior of doxorubicin due to the unique characteristics of the CSS nanomicelles. Photothermal cytotoxicity in vitro confirms that the CDF-Au-shell nanomicelles cause cell death through photothermal effects only under NIR laser irradiation. Cancer cells incubated with CDF-Au-shell nanomicelles show a significant decrease in cell viability only in the presence of both NIR irradiation and a magnetic field, which is attributed to the synergetic effects of the magnetic-field-guided drug delivery and the photothermal therapy. Therefore, such multicomponent nanomicelles can be developed as a smart and promising nanosystem that integrates multiple capabilities for effective cancer diagnosis and therapy.

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