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Magnetic Hydrogels and Their Potential Biomedical Applications

Authors

  • Yuhui Li,

    1. Biomedical Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, 710049, China
    2. State Key Laboratory of Space Biotechnology, Northwestern Polytechnical University, Xi'an, 710072, China
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  • Guoyou Huang,

    1. Biomedical Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, 710049, China
    2. MOE Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China
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  • Xiaohui Zhang,

    1. Biomedical Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, 710049, China
    2. MOE Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China
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  • Baoqiang Li,

    1. Institute for Advanced Ceramics and State, Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150001, China
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  • Yongmei Chen,

    1. Biomedical Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, 710049, China
    2. MOE Key Laboratory for Non-Equilibrium Synthesis and Modulation of Condensed Matter, Department of Chemistry, School of Science, Xi'an Jiaotong University, Xi'an, 710049, China
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  • Tingli Lu,

    1. State Key Laboratory of Space Biotechnology, Northwestern Polytechnical University, Xi'an, 710072, China
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  • Tian Jian Lu,

    Corresponding author
    1. Biomedical Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, 710049, China
    • Biomedical Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, 710049, China.
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  • Feng Xu

    Corresponding author
    1. Biomedical Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, 710049, China
    2. MOE Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China
    • Biomedical Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, 710049, China.
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Abstract

Hydrogels find widespread applications in biomedical engineering due to their hydrated environment and tunable properties (e.g., mechanical, chemical, biocompatible) similar to the native extracellular matrix (ECM). However, challenges still exist regarding utilizing hydrogels in applications such as engineering 3D tissue constructs and active targeting in drug delivery, due to the lack of controllability, actuation, and quick-response properties. Recently, magnetic hydrogels have emerged as a novel biocomposite for their active response properties and extended applications. In this review, the state-of-the-art methods for magnetic hydrogel preparation are presented and their advantages and drawbacks in applications are discussed. The applications of magnetic hydrogels in biomedical engineering are also reviewed, including tissue engineering, drug delivery and release, enzyme immobilization, cancer therapy, and soft actuators. Concluding remarks and perspectives for the future development of magnetic hydrogels are addressed.

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