Full Paper

Modular Multifunctional Poly(ethylene glycol) Hydrogels for Stem Cell Differentiation

  1. Anirudha Singh1,
  2. Jianan Zhan1,
  3. Zhaoyang Ye2,
  4. Jennifer H. Elisseeff1,*

Article first published online: 13 SEP 2012

DOI: 10.1002/adfm.201201902

Issue

Advanced Functional Materials

Advanced Functional Materials

Volume 23, Issue 5, pages 575–582, February 5, 2013

Additional Information

How to Cite

Singh, A., Zhan, J., Ye, Z. and Elisseeff, J. H. (2013), Modular Multifunctional Poly(ethylene glycol) Hydrogels for Stem Cell Differentiation. Adv. Funct. Mater., 23: 575–582. doi: 10.1002/adfm.201201902

Author Information

  1. 1

    Wilmer Eye Institute & Department of Biomedical Engineering, 400 N. Broadway, Robert H. & Clarice Smith Building, Johns Hopkins University, Baltimore, MD 21231, USA

  2. 2

    The State Key Laboratory of Bioreactor Engineering, School of Bioengineering, East China University of Science and Technology, Shanghai-200237, China

*Wilmer Eye Institute & Department of Biomedical Engineering, 400 N. Broadway, Robert H. & Clarice Smith Building, Johns Hopkins University, Baltimore, MD 21231, USA.

Publication History

  1. Issue published online: 1 FEB 2013
  2. Article first published online: 13 SEP 2012
  3. Manuscript Received: 9 JUL 2012

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Keywords:

  • functional biomaterials;
  • poly(ethylene glycol);
  • α-cyclodextrin;
  • tissue engineering;
  • hydrogels

Abstract

Synthetic polymers are employed to create highly defined microenvironments with controlled biochemical and biophysical properties for cell culture and tissue engineering. Chemical modification is required to input biological or chemical ligands, which often changes the fundamental structural properties of the material. Here, a simple modular biomaterial design strategy is reported that employs functional cyclodextrin nanobeads threaded onto poly(ethylene glycol) (PEG) polymer necklaces to form multifunctional hydrogels. Nanobeads with desired chemical or biological functionalities can be simply threaded onto the PEG chains to form hydrogels, creating an accessible platform for users. The design and synthesis of these multifunctional hydrogels are described, structure-property relationships are elucidated, and applications ranging from stem cell culture and differentiation to tissue engineering are demonstrated.

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