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MnO Nanocrystals: A Platform for Integration of MRI and Genuine Autophagy Induction for Chemotherapy

Authors

  • Yang Lu,

    1. Division of Nanomaterials & Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemistry, CAS Key Laboratory of Mechanical Behavior and Design of Materials, the National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230026, P. R. China
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Li Zhang,

    1. Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei 230027, P. R. China
    Current affiliation:
    1. These authors contributed equally to this work.
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  • Jing Li,

    1. Division of Nanomaterials & Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemistry, CAS Key Laboratory of Mechanical Behavior and Design of Materials, the National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230026, P. R. China
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  • Yu-De Su,

    1. Division of Nanomaterials & Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemistry, CAS Key Laboratory of Mechanical Behavior and Design of Materials, the National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230026, P. R. China
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  • Yun Liu,

    1. Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei 230027, P. R. China
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  • Yun-Jun Xu,

    1. Division of Nanomaterials & Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemistry, CAS Key Laboratory of Mechanical Behavior and Design of Materials, the National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230026, P. R. China
    2. Anhui Provincial Hospital, Hefei, 230001, P. R. China
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  • Liang Dong,

    1. Division of Nanomaterials & Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemistry, CAS Key Laboratory of Mechanical Behavior and Design of Materials, the National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230026, P. R. China
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  • Huai-Ling Gao,

    1. Division of Nanomaterials & Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemistry, CAS Key Laboratory of Mechanical Behavior and Design of Materials, the National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230026, P. R. China
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  • Jun Lin,

    1. Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei 230027, P. R. China
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  • Na Man,

    1. Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei 230027, P. R. China
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  • Peng-Fei Wei,

    1. Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei 230027, P. R. China
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  • Wei-Ping Xu,

    1. Anhui Provincial Hospital, Hefei, 230001, P. R. China
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  • Shu-Hong Yu,

    Corresponding author
    1. Division of Nanomaterials & Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemistry, CAS Key Laboratory of Mechanical Behavior and Design of Materials, the National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230026, P. R. China
    • Division of Nanomaterials & Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemistry, CAS Key Laboratory of Mechanical Behavior and Design of Materials, the National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230026, P. R. China
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  • Long-Ping Wen

    Corresponding author
    1. Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei 230027, P. R. China
    • Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, University of Science and Technology of China, Hefei 230027, P. R. China.
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Abstract

Herein, a kind of novel monocomponent hydrophilic and paramagnetic manganese(II) oxide nanocrystal is prepared in polar solution by a one-pot microwave-assisted synthesis. This kind of nanocrystal can be taken up efficiently to serve as an excellent T1 magnetic resonance imaging (MRI) contrast agent with an enhanced r1 value of 0.81 mM−1 s−1. The key to the success of this method is that no additional capping agents are required for coating onto the surface via ligand exchange, facilitating research of their intrinsic biological activities. Furthermore, multiple lines of convincing evidence are presented to prove that MnO nanocrystals (NCs) elicit p53-activation-independent and authentic functional autophagy via inducing autophagosome formation. Notably, there are very few reports so far of the autophagy phenomenon induced by magnetic nanocrystals. Moreover, these results offer an indication for cancer therapy that MnO NCs combined with doxorubicin at a nontoxic concentration can have a definite synergistic effect, which is mediated through the genuine autophagy induction, on killing cancer cells in vitro and in vivo.

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