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Ductile Biodegradable Mg-Based Metallic Glasses with Excellent Biocompatibility

Authors

  • Hai-Jun Yu,

    1. WPI Advanced Institute of Materials Research, Tohoku University, Sendai 980-8577, Japan
    2. Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
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  • Jun-Qiang Wang,

    Corresponding author
    1. WPI Advanced Institute of Materials Research, Tohoku University, Sendai 980-8577, Japan
    • WPI Advanced Institute of Materials Research, Tohoku University, Sendai 980-8577, Japan.
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  • Xue-Tao Shi,

    1. WPI Advanced Institute of Materials Research, Tohoku University, Sendai 980-8577, Japan
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  • Dmitri V. Louzguine-Luzgin,

    1. WPI Advanced Institute of Materials Research, Tohoku University, Sendai 980-8577, Japan
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  • Hong-Kai Wu,

    Corresponding author
    1. WPI Advanced Institute of Materials Research, Tohoku University, Sendai 980-8577, Japan
    2. Department of Chemistry, Hong Kong University of Science and Technology, Hong Kong SAR, China
    • WPI Advanced Institute of Materials Research, Tohoku University, Sendai 980-8577, Japan.
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  • John H. Perepezko

    Corresponding author
    1. WPI Advanced Institute of Materials Research, Tohoku University, Sendai 980-8577, Japan
    2. Department of Materials Science and Engineering, University of Wisconsin-Madison, 1509 University Avenue, Madison, WI 53706, USA
    • WPI Advanced Institute of Materials Research, Tohoku University, Sendai 980-8577, Japan.
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Abstract

Magnesium-based metallic glasses (MMGs) show intriguing potentials for application as implantable biomaterials owing to their disordered atomic structure, good biodegradability, low elastic modulus, high strength, and large elasticity. However, despite of all these advantages, their brittleness is their Achilles’ heel, which severely limits their application as biomedical materials. In the current study, a significantly improved ductility of MMGs under bending and tensile loading through minor alloying with rare-earth element ytterbium (Yb) at an atomic concentration of 2 and 4% is reported. The enhanced ductility is attributed to the increased density of shear bands close to fracture end and larger plastic zones on the fracture surface. In comparison with that of Yb-free control, in vitro cell culture study confirms an improved biocompatibility of MMGs alloyed with Yb as determined by MTT, live-dead, and cytoskeleton staining assays, respectively.

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