Biomedical Applications: Controlling The Mobility Of Oligonucleotides In The Nanochannels Of Mesoporous Silica (Adv. Funct. Mater. 1/2012)

Authors

  • Timo Lebold,

    1. Center for Nanoscience (CeNS) and Center for Integrated Protein, Science Munich (CIPSM), Ludwig-Maximilians-Universität München, Department of Chemistry, Butenandtstraße 11, 81377 Munich, Germany
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  • Axel Schlossbauer,

    1. Center for Nanoscience (CeNS) and Center for Integrated Protein, Science Munich (CIPSM), Ludwig-Maximilians-Universität München, Department of Chemistry, Butenandtstraße 11, 81377 Munich, Germany
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  • Katrin Schneider,

    1. Ludwig-Maximilians-Universität München, Department of Biology, Großhaderner Straße 2, 82152 Planegg-Martinsried, Germany
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  • Lothar Schermelleh,

    1. Ludwig-Maximilians-Universität München, Department of Biology, Großhaderner Straße 2, 82152 Planegg-Martinsried, Germany
    Current affiliation:
    1. University of Oxford, Department of Biochemistry, Oxford OX1 3QU, United Kingdom
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  • Heinrich Leonhardt,

    1. Center for Nanoscience (CeNS) and Center for Integrated Protein, Science Munich (CIPSM), Ludwig-Maximilians-Universität München, Department of Biology, Großhaderner Straße 2, 82152 Planegg-Martinsried, Germany
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  • Thomas Bein,

    Corresponding author
    1. Center for Nanoscience (CeNS) and Center for Integrated Protein, Science Munich (CIPSM), Ludwig-Maximilians-Universität München, Department of Chemistry, Butenandtstraße 11, 81377 Munich, Germany
    • Center for Nanoscience (CeNS) and Center for Integrated Protein, Science Munich (CIPSM), Ludwig-Maximilians-Universität München, Department of Chemistry, Butenandtstraße 11, 81377 Munich, Germany.

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  • Christoph Bräuchle

    Corresponding author
    1. Center for Nanoscience (CeNS) and Center for Integrated Protein, Science Munich (CIPSM), Ludwig-Maximilians-Universität München, Department of Chemistry, Butenandtstraße 11, 81377 Munich, Germany
    • Center for Nanoscience (CeNS) and Center for Integrated Protein, Science Munich (CIPSM), Ludwig-Maximilians-Universität München, Department of Chemistry, Butenandtstraße 11, 81377 Munich, Germany.

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Abstract

original image

Mesoporous silica particles represent a novel, highly versatile class of drug-delivery systems. On page 106, Thomas Bein, Christoph Bräuchle, and co-workers utilize these materials as a host for the incorporation of short oligonucleotides as model gene therapeutics. The diffusion of a labelled oligo-nucleotide through a nanometer-sized silica pore is shown. Organic functionalization of the silica pore system offers a means to control oligonucleotide mobility and stability.

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