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Keywords:

  • polydiacetylene;
  • liposomes;
  • self-assembly;
  • oxime;
  • nerve agents
Thumbnail image of graphical abstract

On page 1632, Jinsang Kim and co-workers report the investigation of polydiacetylene (PDA) liposomes for equipment-free detection of warfare agents. The optimized oxime-modified PDA (OX-PDA) liposome in the solid state shows a selective and rapid optical transition upon exposure to as little as 160 ppb of diisopropylfluorophosphate (DFP), a nerve agent simulant. The results provide an insightful molecular design principle for PDA-based colorimetric sensors and suggest portable sensory patches for rapid, selective, sensitive, and convenient colorimetric detection of organophosphate nerve agents.