Quantum Dots: Ultrasensitive, Biocompatible, Quantum-Dot-Embedded Silica Nanoparticles for Bioimaging (Adv. Funct. Mater. 9/2012)

Authors

  • Bong-Hyun Jun,

    1. School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-747, Korea
    Current affiliation:
    1. Department of Bioengineering University of California Berkeley, Berkeley, CA 94720, USA
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  • Do Won Hwang,

    1. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, 110-744, Korea
    2. Institute of Radiation Medicine, Medical Research Center, Seoul, 110-744, Korea
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  • Heung Su Jung,

    1. Nanosquare Inc. ENG BLD39-122, Seoul National University, Seoul, 151-747, Korea
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  • Jaeho Jang,

    1. WCU Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 151-747, Korea
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  • Hyunsoo Kim,

    1. Nanosquare Inc. ENG BLD39-122, Seoul National University, Seoul, 151-747, Korea
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  • Homan Kang,

    1. Nano Systems Institute and Interdisciplinary Program in Nano-Science and Technology, Seoul National University, Seoul, 151-747, Korea
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  • Taegyu Kang,

    1. School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-747, Korea
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  • San Kyeong,

    1. School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-747, Korea
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  • Hyeokjae Lee,

    1. Nanosquare Inc. ENG BLD39-122, Seoul National University, Seoul, 151-747, Korea
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  • Dae Hong Jeong,

    1. Nano Systems Institute and Interdisciplinary Program in Nano-Science and Technology, Seoul National University, Seoul, 151-747, Korea
    2. Department of Chemistry Education, Seoul National University, Seoul, 151-747, Korea
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  • Keon Wook Kang,

    1. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, 110-744, Korea
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  • Hyewon Youn,

    1. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, 110-744, Korea
    2. Cancer Imaging Center, Seoul National University Cancer Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul, 110-799, Korea
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  • Dong Soo Lee,

    Corresponding author
    1. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, 110-744, Korea
    2. WCU Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 151-747, Korea
    • Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, 110-744, Korea
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  • Yoon-Sik Lee

    Corresponding author
    1. School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-747, Korea
    2. Nano Systems Institute and Interdisciplinary Program in Nano-Science and Technology, Seoul National University, Seoul, 151-747, Korea
    • School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-747, Korea.
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Abstract

original image

On page 1843, Dong Soo Lee, Yoon-Sik Lee, and co-workers investigate very bright quantum dot (QD)-based probes for effective bioimaging. Silica-coated, QD-embedded silica nanoparticles (Si@QDs@Si NPs) containing QDs composed of CdSe@ZnS (core-shell) are prepared to compare the structure-based advantages with single QDs having similar quantum yields. The excellence of Si@QDs@Si NPs is illustrated by significantly enhanced fluorescence signals. The more advanced version of QDs-based silica nanoparticles containing multishell QDs is prepared without significant loss of quantum yield during surface modification.

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