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Biotechnology: Biomolecule Arrays Using Functional Combinatorial Particle Patterning on Microchips (Adv. Funct. Mater. 12/2012)

  1. Felix Loeffler1,
  2. Christopher Schirwitz1,
  3. Jenny Wagner2,
  4. Kai Koenig2,
  5. Frieder Maerkle3,
  6. Gloria Torralba2,
  7. Michael Hausmann2,
  8. F. Ralf Bischoff1,
  9. Alexander Nesterov-Mueller4,*,
  10. Frank Breitling4,*

Article first published online: 6 JUN 2012

DOI: 10.1002/adfm.201290071

Issue

Advanced Functional Materials

Advanced Functional Materials

Volume 22, Issue 12, page 2438, June 20, 2012

Additional Information

How to Cite

Loeffler, F., Schirwitz, C., Wagner, J., Koenig, K., Maerkle, F., Torralba, G., Hausmann, M., Bischoff, F. R., Nesterov-Mueller, A. and Breitling, F. (2012), Biotechnology: Biomolecule Arrays Using Functional Combinatorial Particle Patterning on Microchips (Adv. Funct. Mater. 12/2012). Adv. Funct. Mater., 22: 2438. doi: 10.1002/adfm.201290071

Author Information

  1. 1

    German Cancer Research Center, Chip-based Peptide Libraries Group, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany

  2. 2

    University of Heidelberg, Kirchhoff Institute for Physics, Peptide Chips Group, Im Neuenheimer Feld 227, 69120 Heidelberg, Germany

  3. 3

    Karlsruhe Institute of Technology, Institute of Microstructure Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany

  4. 4

    Karlsruhe Institute of Technology, Institute of Microstructure Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany

*Karlsruhe Institute of Technology, Institute of Microstructure Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany.

Publication History

  1. Issue published online: 6 JUN 2012
  2. Article first published online: 6 JUN 2012

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Keywords:

  • functional particle deposition;
  • solid-phase synthesis;
  • peptide microarrays;
  • biotechnology;
  • high-throughput screening
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On page 2503 Alexander Nesterov-Mueller, Frank Breitling, and co-workers present a microarray system based on a microelectronic chip that allows for a versatile combinatorial molecule synthesis with very high density and, due to the intrinsic alignment, high and reproducible precision. Patterning the chip surface with different microparticle types that embed different monomers allows simultaneous elongation of several thousand different molecule types layer-by-layer.

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