Drug Delivery: Discoidal Porous Silicon Particles: Fabrication and Biodistribution in Breast Cancer Bearing Mice (Adv. Funct. Mater. 20/2012)

Authors

  • Biana Godin,

    Corresponding author
    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
    • Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA.
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  • Ciro Chiappini,

    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
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  • Srimeenakshi Srinivasan,

    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
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  • Jenolyn F. Alexander,

    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
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  • Kenji Yokoi,

    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
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  • Mauro Ferrari,

    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
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  • Paolo Decuzzi,

    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
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  • Xuewu Liu

    Corresponding author
    1. Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA
    • Department of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave, Houston, TX 77030, USA.
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Abstract

original image

Porous silicon (pSi) disks, rendered from a scanning electron microscopy (SEM) image, are shown on the background of an immuno-histochemistry fluorescent microscopy image from a breast tumor. On page 4225, Biana Godin, Xuewu Liu, and co-workers describe the microfabrication of discoidal pSi nanoparticles with precisely controlled morphologies made by direct photolithographic patterning and demonstrate the geometry-dependent, preferable accumulation of the pSi disks over spherical nanoparticles in orthotopic murine models of breast cancer.

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