Cell Separation: Ethanol-Dispersed Polymer Nanofibers as a Highly Selective Cell Isolation and Release Platform for CD4+ T Lymphocytes (Adv. Funct. Mater. 21/2012)

Authors

  • Seung-Hyun Jun,

    1. Department of Chemical and Biological Engineering, Korea University, Seoul 136-713, Republic of Korea
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  • Kwanghee Kim,

    1. Global Research Laboratory, Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul 136-713, Republic of Korea
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  • Hyo Jin An,

    1. Department of Chemical and Biological Engineering, Korea University, Seoul 136-713, Republic of Korea
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  • Byoung Chan Kim,

    1. Environment Sensor System Research Center, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea
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  • Chung Hee Sonn,

    1. Global Research Laboratory, Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul 136-713, Republic of Korea
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  • Miju Kim,

    1. Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Gyeongbuk 790-784, Republic of Korea
    2. School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk 790-784, Republic of Korea
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  • Junsang Doh,

    1. Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Gyeongbuk 790-784, Republic of Korea
    2. School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk 790-784, Republic of Korea
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  • Cassian Yee,

    1. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 USA
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  • Kyung-Mi Lee,

    Corresponding author
    1. Global Research Laboratory, Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul 136-713, Republic of Korea
    • Global Research Laboratory, Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul 136-713, Republic of Korea.
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  • Jungbae Kim

    Corresponding author
    1. Department of Chemical and Biological Engineering, Korea University, Seoul 136-713, Republic of Korea
    • Department of Chemical and Biological Engineering, Korea University, Seoul 136-713, Republic of Korea
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Abstract

original image

Electrospun and alcohol-dispersed polystyrene-poly(styreneco-maleic anhydride) (PS-PSMA) nanofibers, which allow for facile conjugation of antibodies, are used as an innovative cell isolation/enrichment and support/release platform. As reported by Kyung-Mi Lee, Jungbae Kim, and co-workers on page 4448, this work opens up the potential for an innovative immune cell therapy in which specific immune cells are isolated by antibody-conjugated nanofibers and are directly delivered to the target sites under the controlled and sustained release of immune cells via in vivo activation.

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