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Nucleoside Triphosphates as Promoters to Enhance Nanoceria Enzyme-like Activity and for Single-Nucleotide Polymorphism Typing

Authors

  • Can Xu,

    1. Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, China
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  • Zhen Liu,

    1. Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, China
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  • Li Wu,

    1. Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, China
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  • Jinsong Ren,

    1. Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, China
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  • Xiaogang Qu

    Corresponding author
    1. Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, China
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Abstract

Nucleoside triphosphates (NTPs) can improve the oxidase-like activity of nanoceria and the enhancement is correlated with the type of NTP. This effect is demonstrated to be as a result of the coupling of the oxidative reaction with the NTP hydrolysis reactions, as the nanoceria has both oxidase-like and phosphatase-like activities. The differences reflect the different dephosphorylation catalytic activities of nanoceria to the NTP used. Furthermore, based on the NTP-promoted oxidase-like activity of nanoceria and the differences among the different types of NTPs, series effective and high-throughput colorimetric assays for single-nucleotide polymorphism (SNP) typing are developed.

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