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Highly Bright and Compact Alloyed Quantum Rods with Near Infrared Emitting: a Potential Multifunctional Nanoplatform for Multimodal Imaging In Vivo

Authors

  • Duyang Gao,

    1. CAS Key Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedicine, Shenzhen Key Laboratory of Cancer Nanotechnology, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
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  • Pengfei Zhang,

    1. CAS Key Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedicine, Shenzhen Key Laboratory of Cancer Nanotechnology, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
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  • Zonghai Sheng,

    1. CAS Key Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedicine, Shenzhen Key Laboratory of Cancer Nanotechnology, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
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  • Dehong Hu,

    1. CAS Key Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedicine, Shenzhen Key Laboratory of Cancer Nanotechnology, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
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  • Ping Gong,

    1. CAS Key Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedicine, Shenzhen Key Laboratory of Cancer Nanotechnology, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
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  • Chi Chen,

    1. CAS Key Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedicine, Shenzhen Key Laboratory of Cancer Nanotechnology, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
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  • Qian Wan,

    1. P. C. Lauterbur, Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
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  • Guanhui Gao,

    1. CAS Key Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedicine, Shenzhen Key Laboratory of Cancer Nanotechnology, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
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  • Lintao Cai

    Corresponding author
    1. CAS Key Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedicine, Shenzhen Key Laboratory of Cancer Nanotechnology, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
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Abstract

Controlling synthesis of near-infrared emitting quantum rods (QRs) for in vivo imaging is a major challenge in the fabrication of multifunctional nanoprobes. Here, a reliable synthetic approach for CdTe x Se1–x /ZnS alloy nanocrystals to achieve highly bright (quantum yields up to 80%) with controllable rod-shape and near-infrared (650–870 nm) emission is developed. Aspect ratio and emission of QRs are correlated with composition, which can be easily tuned by changing Te and Se mole ratio. It illustrates that the content of Se plays an important role in maintaining the rod-shape, while Te has a significant impact on emitting of the nanorods. Besides exhibiting great stability over a broad range of pH (4–10) and ion strength (up to 2 mol L-1 NaCl solution), these hydrophilic QRs display good photo stability and storage stability. In particular, the specially absorbing of paramagnetic gadolinium ions on the QRs lead to a versatile method to engineer multimodal imaging nanoprobes, which are applied for in vivo lymph node dual-modal imaging (fluorescence and magnetic resonance imaging). These results suggest a promising strategy for engineering multifunctional imaging nanoprobes with the stable near-infrared QRs.

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