Biomedical Applications: Multilayered Blood Capillary Analogs in Biodegradable Hydrogels for In Vitro Drug Permeability Assays (Adv. Funct. Mater. 14/2013)

Authors

  • Hiroaki Yoshida,

    1. Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Osaka 565-0871, Japan
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  • Michiya Matsusaki,

    1. Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Osaka 565-0871, Japan
    2. PRESTO, Japan Science and Technology Agency (JST), 4-1-8 Honcho Kawaguchi, Saitama, Japan
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  • Mitsuru Akashi

    Corresponding author
    1. Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Osaka 565-0871, Japan
    • Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
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Abstract

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Multilayered blood capillary analogs are constructed in biodegradable hydrogels as reported by Mitsuru Akashi and co-workers on page 1736. The size, orientation, length, layer, and cell type of the artificial blood capillaries are easily controlled. Additionally, permeability control of serum albumin by altering blood vessel cell layers is demonstrated. This technique will be useful as an innovative technology for drug permeability assessment to human blood vessels.

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