Bioinspired Materials: Hyaluronic Acid Catechol: A Biopolymer Exhibiting a pH-Dependent Adhesive or Cohesive Property for Human Neural Stem Cell Engineering (Adv. Funct. Mater. 14/2013)

Authors

  • Seonki Hong,

    1. Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), KAIST Institute for the BioCentury, Daejeon 305-701, S. Korea
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  • Kisuk Yang,

    1. Department of Biotechnology, Yonsei University, Seoul 120-749, S. Korea
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  • Bobae Kang,

    1. Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), KAIST Institute for the BioCentury, Daejeon 305-701, S. Korea
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  • Changhyun Lee,

    1. Department of Biotechnology, Yonsei University, Seoul 120-749, S. Korea
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  • In Taek Song,

    1. Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), KAIST Institute for the BioCentury, Daejeon 305-701, S. Korea
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  • Eunkyoung Byun,

    1. Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), KAIST Institute for the BioCentury, Daejeon 305-701, S. Korea
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  • Kook In Park,

    1. Department of Pediatrics and BK21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul 120-752, S. Korea
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  • Seung-Woo Cho,

    Corresponding author
    1. Department of Biotechnology, Yonsei University, Seoul 120-749, S. Korea
    • Department of Biotechnology, Yonsei University, Seoul 120-749, S. Korea
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  • Haeshin Lee

    Corresponding author
    1. Department of Chemistry, The Graduate School of Nanoscience and Technology (WCU), KI NanoCentury, Korea Advanced Institute of Science and Technology (KAIST), 291 University Rd, Daejeon 305-701, S. Korea
    • Department of Chemistry, The Graduate School of Nanoscience and Technology (WCU), KI NanoCentury, Korea Advanced Institute of Science and Technology (KAIST), 291 University Rd, Daejeon 305-701, S. Korea.
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Abstract

original image

A mussel, which is a sticky organism underwater, provides researchers inspiration to develop novel bio-adhesives. Catechol is a key chemical moiety for developing such adhesives. The results reported by Seung-Woo Cho, Haeshin Lee, and co-workers on page 1774 show the dual roles of catechol, with its properties of cohesion and adhesion depending on environmental conditions such as pH. Catechol is chemically tethered onto hyaluronic acid and the resulting conjugate is demonstrated to be useful for human neural stem cell culture.

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