Biomedical Applications: Imaging-Guided pH-Sensitive Photodynamic Therapy Using Charge Reversible Upconversion Nanoparticles under Near-Infrared Light (Adv. Funct. Mater. 24/2013)

Authors

  • Chao Wang,

    1. Jiangsu Key Laboratory for Carbon-Based, Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, PR China
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  • Liang Cheng,

    1. Jiangsu Key Laboratory for Carbon-Based, Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, PR China
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  • Yumeng Liu,

    1. Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, PR China
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  • Xiaojing Wang,

    1. Jiangsu Key Laboratory for Carbon-Based, Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, PR China
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  • Xinxing Ma,

    1. Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, PR China
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  • Zhaoyi Deng,

    1. Department of Earth and Space Science, University of Science and Technology of China, Hefei, Anhui, 230026, PR China
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  • Yonggang Li,

    1. Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, PR China
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  • Zhuang Liu

    Corresponding author
    1. Jiangsu Key Laboratory for Carbon-Based, Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, PR China
    • Jiangsu Key Laboratory for Carbon-Based, Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, PR China.
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Abstract

original image

Smart charge-reversible upconversion nanoparticles are reported on page 3077 by Zhuang Liu and co-workers for pH-responsive, in vivo, near-infrared light excited photodynamic therapy. While stable under normal physiological pH, highly sensitive acid-induced charge conversion of the nanoparticles is observed in a slightly acidic tumor microenvironment, resulting in significantly enhanced cellular internalization of nanoparticles and remarkably improved photodynamic cancer cell killing in vitro and in vivo.

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