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Keywords:

  • sensors;
  • quantum dots;
  • signal amplifiers;
  • porous materials;
  • interferometry
Thumbnail image of graphical abstract

G. Gaur, D. S. Koktysh, and S. M. Weiss report on page 3604 a dual-mode optical biosensor that incorporates quantum dots as refractive index signal amplifiers and bio-recognition fluorescence probes in a three-dimensional nanoporous silicon matrix. The inherently size-selective nanopores with extremely high surface areas support the highly efficient capture and immobilization of quantum dot-labeled target biomolecules. This approach is promising for sensitive and low-cost point-of-care diagnostics.