Functional Biomaterials: Highly Elastic Micropatterned Hydrogel for Engineering Functional Cardiac Tissue (Adv. Funct. Mater. 39/2013)

Authors

  • Nasim Annabi,

    1. Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
    2. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA
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  • Kelly Tsang,

    1. Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
    2. Department of Materials Engineering, Monash University, Melbourne, Victoria, Australia
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  • Suzanne M. Mithieux,

    1. School of Molecular Bioscience, University of Sydney, Sydney, 2006, Australia
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  • Mehdi Nikkhah,

    1. Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
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  • Afshin Ameri,

    1. Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
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  • Ali Khademhosseini,

    Corresponding author
    1. Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
    2. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA
    • Ali Khademhosseini, Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA

      Anthony S. Weiss, School of Molecular Bioscience, University of Sydney, Sydney, 2006, Australia.

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  • Anthony S. Weiss

    Corresponding author
    1. School of Molecular Bioscience, University of Sydney, Sydney, 2006, Australia
    2. Charles Perkins Centre, University of Sydney, Sydney, 2006, Australia
    3. Bosch Institute, University of Sydney, Sydney, 2006, Australia
    • Ali Khademhosseini, Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA, Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA

      Anthony S. Weiss, School of Molecular Bioscience, University of Sydney, Sydney, 2006, Australia.

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Abstract

original image

Tropoelastin is crosslinked with methacrylation and light to make MeTro. MeTro enables encapsulation and surface interactions with cells, as shown by A. Khademhosseini, A. S. Weiss, and co-workers on page 4950. Patterned MeTro is elastic and supports the organized growth of functionally active, beating cardiomyocytes. Immunostaining shows α-sarcomeric actinin (green), connexin-43 (red), and nuclei (blue).

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