Micropatterning: Regulation of Stem Cell Fate in a Three-Dimensional Micropatterned Dual-Crosslinked Hydrogel System (Adv. Funct. Mater. 38/2013)

Authors

  • Oju Jeon,

    1. Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA
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  • Eben Alsberg

    Corresponding author
    1. Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA
    2. Department of Orthopaedic Surgery, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA
    • Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA.
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Abstract

original image

3D, dual-crosslinked, oxidized hydrogels with spatially tunable physical properties are micropatterned on page 4765 by O. Jeon and E. Alsberg. Photoencapsulated human adipose-derived stem cell proliferation rate and osteogenic and chondrogenic differentiation are found to be functions of the micropattern size. The physical properties in this system therefore introduce a new parameter for regulating various cellular behaviors, and a novel platform for studying the proliferation and differentiation of stem cells in a spatially controlled manner for tissue engineering and regenerative medicine applications.

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