Cancer Theranostics: Ultra-Small Iron Oxide Doped Polypyrrole Nanoparticles for In Vivo Multimodal Imaging Guided Photothermal Therapy (Adv. Funct. Mater. 9/2014)

Authors

  • Xuejiao Song,

    1. Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu, China
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  • Hua Gong,

    1. Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu, China
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  • Shengnan Yin,

    1. Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
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  • Liang Cheng,

    1. Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu, China
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  • Chao Wang,

    1. Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu, China
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  • Zhiwei Li,

    1. Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu, China
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  • Yonggang Li,

    1. Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
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  • Xiaoyong Wang,

    1. Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
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  • Gang Liu,

    1. Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China
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  • Zhuang Liu

    Corresponding author
    1. Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu, China
    • Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou Jiangsu 215123 China

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Abstract

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Polypyrrole (PPy), a NIR-absorbing conjugate polymer, is used by Z. Liu and co-workers to coat iron oxide nanoparticles (IONPs), obtaining IONP@PPy core–shell nanoparticles, further modified by polyethylene glycol. On page 1194, the obtained multifunctional nanoparticles are guided by dual-modal magnetic resonance and photoacoustic imaging for in vivo photothermal therapy, achieving an excellent tumor ablation therapeutic effect in a mouse model. These results promise the use of multifunctional NIR-absorbing organic–inorganic hybrid nanomaterials for applications in cancer theranostics.

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