Cancer Treatment: Photothermal Killing of Cancer Cells by the Controlled Plasmonic Coupling of Silica-Coated Au/Fe2O3 Nanoaggregates (Adv. Funct. Mater. 19/2014)

Authors

  • Georgios A. Sotiriou,

    1. Particle Technology Laboratory, Institute of Process Engineering, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland
    2. Department of Environmental Health, Harvard University, Boston, MA, USA
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  • Fabian Starsich,

    1. Particle Technology Laboratory, Institute of Process Engineering, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland
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  • Athanasia Dasargyri,

    1. Drug Formulation & Delivery, Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland
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  • Moritz C. Wurnig,

    1. Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland
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  • Frank Krumeich,

    1. Particle Technology Laboratory, Institute of Process Engineering, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland
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  • Andreas Boss,

    1. Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland
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  • Jean-Christophe Leroux,

    1. Drug Formulation & Delivery, Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland
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  • Sotiris E. Pratsinis

    Corresponding author
    1. Particle Technology Laboratory, Institute of Process Engineering, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland
    • Particle Technology Laboratory, Institute of Process Engineering===, Department of Mechanical and Process Engineering, ETH Zurich===, Sonneggstrasse 3===, CH-8092=== Zurich=== Switzerland=== ===

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Abstract

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Hybrid plasmonic-superparamagnetic nanoaggregates are encapsulated by a nanothin amorphous silica film inflight during their gas-phase synthesis. By varying that film thickness, S. E. Pratsinis and co-workers can fine-tune the interparticle distance among individual gold nanoparticles, inducing their controlled plasmonic coupling. In this way, the nanoaggregate optical absorption is shifted to the NIR, facilitating their efficient light-into-heat photothermal performance. The superparamagnetic component of nanoaggregates enables their magnetic manipulation and MRI detection. These multifunctional nanoaggregates kill breast cancer cells by NIR irradiation, rendering such particles suitable for theranostics.

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