Controlled Degradability of Polysaccharide Multilayer Films In Vitro and In Vivo (pages 1771–1780)
C. Picart, A. Schneider, O. Etienne, J. Mutterer, P. Schaaf, C. Egles, N. Jessel and J.-C. Voegel
Article first published online: 12 OCT 2005 | DOI: 10.1002/adfm.200400588
Polysaccharide multilayer film degradation can be tuned via control of film crosslinking and component molecular weight. Studies performed in vitro and in vivo confirm that films of chitosan/hyaluronan layers are more resistant to enzymatic and macrophage degradation when crosslinked (see Figure: right panel, increased crosslinking, scale bar 110 μm) or formed with medium-molecular-weight chitosan. Applications as biodegradable coatings are envisaged.