Design of Gold Nanoparticles for Magnetic Resonance Imaging (pages 2330–2339)
P.-J. Debouttière, S. Roux, F. Vocanson, C. Billotey, O. Beuf, A. Favre-Réguillon, Y. Lin, S. Pellet-Rostaing, R. Lamartine, P. Perriat and O. Tillement
Article first published online: 3 NOV 2006 | DOI: 10.1002/adfm.200600242
A novel magnetic resonance imaging contrast agent has been developed based on gadolinium chelates immobilized on gold nanoparticles. As shown in the figure, the robust multilayered ligand shell formed around the gold particles is able to bind many gadolinium ions, thereby yielding much greater contrast per contrast agent as compared to free gadolinium chelates.