In vivo Cellular Uptake, Degradation, and Biocompatibility of Polyelectrolyte Microcapsules (pages 3754–3763)
S. De Koker, B. G. De Geest, C. Cuvelier, L. Ferdinande, W. Deckers, W. E. Hennink, S. C. De Smedt and N. Mertens
Article first published online: 28 NOV 2007 | DOI: 10.1002/adfm.200700416
The in vivo cellular uptake, degradation and biocompatibility of polyelectrolyte microcapsules produced from alternating dextran sulphate and poly-L-arginine layers on a template of calcium carbonate microparticles is reported. A moderate tissue reaction is observed after subcutaneous injection of polyelectrolyte microcapsules in mice. Within sixteen days after subcutaneous injection, most of the microcapsules are internalized by the cells and start to degrade. The number of polyelectrolyte layers determines the stability of the microcapsules after cellular uptake.