Adenoviral Gene Delivery from Multilayered Polyelectrolyte Architectures (pages 233–245)
M. Dimitrova, Y. Arntz, P. Lavalle, F. Meyer, M. Wolf, C. Schuster, Y. Haïkel, J.-C. Voegel and J. Ogier
Article first published online: 19 DEC 2006 | DOI: 10.1002/adfm.200600155
A bioactive adenoviral vector is embedded into multilayered polyelectrolyte films. Ad efficiently adsorbs on poly(L-lysine)–poly(L-glutamic acid), poly(L-lysine)–hyaluronan, poly(allylamin hydrochloride)–poly(sodium-4-styrenesulfonate) (see the AFM image), and chitosan–hyaluronan films, and preserves its transduction capacity for a large number of cell types.