Pathogen-Mimicking MnO Nanoparticles for Selective Activation of the TLR9 Pathway and Imaging of Cancer Cells (pages 3717–3725)
Mohammed Ibrahim Shukoor, Filipe Natalio, Muhammad Nawaz Tahir, Matthias Wiens, Marco Tarantola, Helen Annal Therese, Matthias Barz, Stefan Weber, Maxim Terekhov, Heinz C. Schröder, Werner E. G. Müller, Andreas Janshoff, Patrick Theato, Rudolf Zentel, Laura Maria Schreiber and Wolfgang Tremel
Article first published online: 26 OCT 2009 | DOI: 10.1002/adfm.200900635
Pathogen-mimicking metal oxide nanoparticles with the ability to enter and to selectively target and activate the TLR9 pathway in cancer cells with optical and MR imaging capabilities are prepared. A multifunctional polymer is used as an interface for the nanoparticle surface modification that affords a protective organic biocompatible shell and provides an efficient and convenient means for loading the immunostimulatory oligonucleotides. These nanoparticles allow for monitoring of the nanoparticle cellular trafficking by optical and magnetic resonance imaging and can also be used for drug delivery.