Multifunctional Mesoporous Nanoellipsoids for Biological Bimodal Imaging and Magnetically Targeted Delivery of Anticancer Drugs (pages 270–278)
Yu Chen, Hangrong Chen, Shengjian Zhang, Feng Chen, Lingxia Zhang, Jiamin Zhang, Min Zhu, Huixia Wu, Limin Guo, Jingwei Feng and Jianlin Shi
Article first published online: 26 OCT 2010 | DOI: 10.1002/adfm.201001495
A polyelectrolyte mediated self-assembly technique is used to prepare mesoporous nanostructures for biological bimodal imaging and magnetically targeted delivery of anticancer drugs (doxorubicin). Positively charged polyelectrolyte and negatively charged fluorescent quantum dots are assembled onto the surface of ellipsoidal Fe3O4@SiO2@mSiO2 nanostructures to combine tunable fluorescent/magnetic properties with mesoporous ellipsoidal nanostructures for enhanced cancer-cell uptake, endowing multifunctional capabilities for chemotherapy of cancers.