A Biologically Active Surface Enzyme Assembly that Attenuates Thrombus Formation (pages 4736–4743)
Zheng Qu, Sharmila Muthukrishnan, Murali K. Urlam, Carolyn A. Haller, Sumanas W. Jordan, Vivek A. Kumar, Ulla M. Marzec, Yaseen Elkasabi, Joerg Lahann, Stephen R. Hanson and Elliot L. Chaikof
Article first published online: 26 SEP 2011 | DOI: 10.1002/adfm.201101687
A biologically active thrombomodulin surface assembly to limit interfacial thrombin production was generated on the lumen of clinical ePTFE vascular grafts by site-specific covalent immobilization. Therapeutic capacity of this biomimetic surface engineering approach to attenuate thrombus formation was demonstrated in a clinically relevant in vivo model of prosthetic graft thrombosis.