Engineering Inorganic Nanoemulsions/Nanoliposomes by Fluoride-Silica Chemistry for Efficient Delivery/Co-Delivery of Hydrophobic Agents (pages 1586–1597)
Yu Chen, Yu Gao, Hangrong Chen, Deping Zeng, Yaping Li, Yuanyi Zheng, Faqi Li, Xiufeng Ji, Xia Wang, Feng Chen, Qianjun He, Linlin Zhang and Jianlin Shi
Article first published online: 2 FEB 2012 | DOI: 10.1002/adfm.201102052
A simple and efficient drug-formulation protocol is developed to solve the delivery problem of hydrophobic agents. The protocol uses inorganic mesoporous silica nanocapsules as a promising alternative to traditional organic emulsions and liposomes while preserving the advantages of inorganic materials. This is demonstrated by delivery of drugs for cancer chemotherapy and surgery as well as the co-delivery of molecules for enhanced chemotherapy of drug-resistant cancer.