Ultrasensitive, Biocompatible, Quantum-Dot-Embedded Silica Nanoparticles for Bioimaging (pages 1843–1849)
Bong-Hyun Jun, Do Won Hwang, Heung Su Jung, Jaeho Jang, Hyunsoo Kim, Homan Kang, Taegyu Kang, San Kyeong, Hyeokjae Lee, Dae Hong Jeong, Keon Wook Kang, Hyewon Youn, Dong Soo Lee and Yoon-Sik Lee
Article first published online: 17 FEB 2012 | DOI: 10.1002/adfm.201102930
Very bright quantum dot (QD)-based probes consisting of QDs on 120 nm silica nanoparticles with silica shells are investigated for effective bioimaging. Silica-coated, QD-embedded silica nanoparticles exhibit approximately 200-times stronger photoluminescence (PL) than single QDs. The more advanced version of QD-based silica nanoparticles containing multishell QDs can detect as few as 400 units of nanoparticle-internalized cells in a cell-implanted mouse model.