MnO Nanocrystals: A Platform for Integration of MRI and Genuine Autophagy Induction for Chemotherapy (pages 1534–1546)
Yang Lu, Li Zhang, Jing Li, Yu-De Su, Yun Liu, Yun-Jun Xu, Liang Dong, Huai-Ling Gao, Jun Lin, Na Man, Peng-Fei Wei, Wei-Ping Xu, Shu-Hong Yu and Long-Ping Wen
Article first published online: 26 OCT 2012 | DOI: 10.1002/adfm.201202233
Hydrophilic MnO nanocrystals can be prepared by a one-pot microwave-assisted synthesis in a polar solvent. In addition to serving as an outstanding T1-magnetic resonance (MR) contrast agent directly, the obtained MnO nanocrystals can induce genuine autophagy. This kind of MnO nanocrystal provides a new platform for combinatorial treatment of cancers via the synergistic effects of nanocrystals and doxorubicin in killing cancer cells.