Remote-Controlled Hydrogel Depots for Time-Scheduled Vaccination (pages 5355–5362)
Raphael J. Gübeli, Désirée Hövermann, Hanna Seitz, Balder Rebmann, Ronald G. Schoenmakers, Martin Ehrbar, Ghislaine Charpin-El Hamri, Marie Daoud-El Baba, Martin Werner, Martin Müller and Wilfried Weber
Article first published online: 5 JUN 2013 | DOI: 10.1002/adfm.201300875
A pharmacologically controlled hydrogel depot is presented allowing for the scheduled induction of a medical response in vivo. The vaccine-loaded hydrogel depot is administered to mice. At the desired point in time, the vaccine can be released from the depot by the oral administration of the stimulus molecule fluorescein resulting in protective immunization.