Liver-Specific and Echogenic Hyaluronic Acid Nanoparticles Facilitating Liver Cancer Discrimination (pages 5518–5529)
Hyun Su Min, Sejin Son, Tae Woong Lee, Heebeom Koo, Hong Yeol Yoon, Jin Hee Na, Yongseok Choi, Jae Hyung Park, Jaeyoung Lee, Moon Hee Han, Rang-Woon Park, In-San Kim, Seo Young Jeong, Kyehan Rhee, Sun Hwa Kim, Ick Chan Kwon and Kwangmeyung Kim
Article first published online: 19 JUN 2013 | DOI: 10.1002/adfm.201301131
A new species of echogenic hyaluronic acid (HA) nanoparticles is presented as an ultralong-acting, liver-specific, ultrasound contrast agent (UCA) that is distinct from conventional gas-filled microbubbles. The approach of utilizing preformulated solid nanoparticles as templates to load liquid gas precursors provides advantages in the construction of a long-acting UCAs and greatly improved echogenic properties are observed.