Multifunctional Graphene Oxide-based Triple Stimuli-Responsive Nanotheranostics (pages 4386–4396)
Yu Chen, Pengfei Xu, Zhu Shu, Meiying Wu, Lianzhou Wang, Shengjian Zhang, Yuanyi Zheng, Hangrong Chen, Jin Wang, Yaping Li and Jianlin Shi
Article first published online: 1 APR 2014 | DOI: 10.1002/adfm.201400221
A triple-functional biocompatible stimuli-responsive nanosystem based on the functionalized nanographene oxides is developed by a novel and efficient double redox strategy. This elaborately designed nanographene oxide-based nanoplatform exhibits the unique triple stimuli-responsivenesses for biomedical engineering, including pH-responsive drug release to inhibit the metastasis and reverse the multidrug resistance of cancer cells, pH-/redox-responsive magnetic resonance imaging and magnetic field-responsive hyperthermia of cancer.