A Highly Sensitive Gold-Nanoparticle-Based Assay for Acetylcholinesterase in Cerebrospinal Fluid of Transgenic Mice with Alzheimer's Disease

Authors

  • Dingbin Liu,

    1. CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Beiyitiao, Zhongguancun, Beijing, 100190, P. R. China
    2. Graduate University of Chinese Academy of Sciences, Shijingshan, Yuquan Road, 19(A), Beijing, 100049, P. R. China
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  • Wenwen Chen,

    1. CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Beiyitiao, Zhongguancun, Beijing, 100190, P. R. China
    2. Graduate University of Chinese Academy of Sciences, Shijingshan, Yuquan Road, 19(A), Beijing, 100049, P. R. China
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  • Yue Tian,

    1. CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Beiyitiao, Zhongguancun, Beijing, 100190, P. R. China
    2. Graduate University of Chinese Academy of Sciences, Shijingshan, Yuquan Road, 19(A), Beijing, 100049, P. R. China
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  • Sha He,

    1. CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Beiyitiao, Zhongguancun, Beijing, 100190, P. R. China
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  • Wenfu Zheng,

    1. CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Beiyitiao, Zhongguancun, Beijing, 100190, P. R. China
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  • Jiashu Sun,

    1. CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Beiyitiao, Zhongguancun, Beijing, 100190, P. R. China
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  • Zhuo Wang,

    Corresponding author
    1. CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Beiyitiao, Zhongguancun, Beijing, 100190, P. R. China
    • CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Beiyitiao, Zhongguancun, Beijing, 100190, P. R. China.

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  • Xingyu Jiang

    Corresponding author
    1. CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Beiyitiao, Zhongguancun, Beijing, 100190, P. R. China
    • CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 11 Beiyitiao, Zhongguancun, Beijing, 100190, P. R. China.

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Abstract

original image

A highly sensitive, selective, and dual-readout (colorimetric and fluorometric) assay for acetylcholinesterase (AChE) based on Rhodamine B-modified gold nanoparticle is reported. Due to its good sensitivity and selectivity, the assay can be used for monitoring AChE levels in the cerebrospinal fluid of transgenic mice with Alzheimer's disease.

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