A Novel Microfluidic Approach for Monodispersed Chitosan Microspheres with Controllable Structures

Authors

  • Jian-Hong Xu,

    Corresponding author
    1. The State Key Lab of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, 100084, Beijing, P. R. China
    • The State Key Lab of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, 100084, Beijing, P. R. China.

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  • Hong Zhao,

    1. The State Key Lab of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, 100084, Beijing, P. R. China
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  • Wen-Jie Lan,

    1. The State Key Lab of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, 100084, Beijing, P. R. China
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  • Guang-Sheng Luo

    Corresponding author
    1. The State Key Lab of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, 100084, Beijing, P. R. China
    • The State Key Lab of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, 100084, Beijing, P. R. China.

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Abstract

original image

A novel and simple approach to prepare monodispersed chitosan microspheres with relative small size and controlled structures was developed by combining the solidification methods of solvent extraction and chemical crosslinking in a capillary-embedded microfluidic decive. The microspheres with different structures are used in the field of protein drug controlled release and immobilization lipases and they show different release profiles and good stability, respectively.

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