Communication

Cascaded Photoinduced Drug Delivery to Cells from Multifunctional Core–Shell Mesoporous Silica

  1. Axel Schloßbauer1,
  2. Anna M. Sauer1,
  3. Valentina Cauda1,
  4. Alexandra Schmidt1,
  5. Hanna Engelke2,
  6. Ulrich Rothbauer3,
  7. Kourosh Zolghadr3,
  8. Heinrich Leonhardt3,
  9. Christoph Bräuchle1,*,
  10. Thomas Bein1,*

Article first published online: 2 APR 2012

DOI: 10.1002/adhm.201100033

Issue

Advanced Healthcare Materials

Advanced Healthcare Materials

Volume 1, Issue 3, pages 316–320, May, 2012

Additional Information

How to Cite

Schloßbauer, A., Sauer, A. M., Cauda, V., Schmidt, A., Engelke, H., Rothbauer, U., Zolghadr, K., Leonhardt, H., Bräuchle, C. and Bein, T. (2012), Cascaded Photoinduced Drug Delivery to Cells from Multifunctional Core–Shell Mesoporous Silica. Advanced Healthcare Materials, 1: 316–320. doi: 10.1002/adhm.201100033

Author Information

  1. 1

    Department of Chemistry and Biochemistry and Center for NanoScience, University of Munich (LMU), Butenandtstrasse 5-13 (E), 81377 Munich, Germany

  2. 2

    Department of Physics and Center for Nanoscience, University of Munich (LMU), Geschwister-Scholl-Platz 1, 80539 Munich, Germany

  3. 3

    BioCenter and Center for NanoScience (CeNS), University of Munich (LMU), Grosshadernerstr. 2, 82152 Planegg-Martinsried, Germany

*Department of Chemistry and Biochemistry and Center for NanoScience, University of Munich (LMU), Butenandtstrasse 5-13 (E), 81377 Munich, Germany.

Publication History

  1. Issue published online: 4 MAY 2012
  2. Article first published online: 2 APR 2012
  3. Manuscript Revised: 20 JAN 2012
  4. Manuscript Received: 30 NOV 2011

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Keywords:

  • drug delivery;
  • colloids;
  • fluorescence microscopy;
  • mesoporous silica;
  • host-guest systems;
  • photosensitizer
Thumbnail image of graphical abstract

Different bioactive molecules are released into living cells from lipid-covered mesoporous silica nanoparticles. The release is triggered by light, as the particles feature covalently attached photosensitizers as membrane-opening agents. It is demonstrated that the particles achieve endosomal escape and that they release their cargo into the cytosol.

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