Cascaded Photoinduced Drug Delivery to Cells from Multifunctional Core–Shell Mesoporous Silica

Authors

  • Axel Schloßbauer,

    1. Department of Chemistry and Biochemistry and Center for NanoScience, University of Munich (LMU), Butenandtstrasse 5-13 (E), 81377 Munich, Germany
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  • Anna M. Sauer,

    1. Department of Chemistry and Biochemistry and Center for NanoScience, University of Munich (LMU), Butenandtstrasse 5-13 (E), 81377 Munich, Germany
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  • Valentina Cauda,

    1. Department of Chemistry and Biochemistry and Center for NanoScience, University of Munich (LMU), Butenandtstrasse 5-13 (E), 81377 Munich, Germany
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  • Alexandra Schmidt,

    1. Department of Chemistry and Biochemistry and Center for NanoScience, University of Munich (LMU), Butenandtstrasse 5-13 (E), 81377 Munich, Germany
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  • Hanna Engelke,

    1. Department of Physics and Center for Nanoscience, University of Munich (LMU), Geschwister-Scholl-Platz 1, 80539 Munich, Germany
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  • Ulrich Rothbauer,

    1. BioCenter and Center for NanoScience (CeNS), University of Munich (LMU), Grosshadernerstr. 2, 82152 Planegg-Martinsried, Germany
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  • Kourosh Zolghadr,

    1. BioCenter and Center for NanoScience (CeNS), University of Munich (LMU), Grosshadernerstr. 2, 82152 Planegg-Martinsried, Germany
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  • Heinrich Leonhardt,

    1. BioCenter and Center for NanoScience (CeNS), University of Munich (LMU), Grosshadernerstr. 2, 82152 Planegg-Martinsried, Germany
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  • Christoph Bräuchle,

    Corresponding author
    1. Department of Chemistry and Biochemistry and Center for NanoScience, University of Munich (LMU), Butenandtstrasse 5-13 (E), 81377 Munich, Germany
    • Department of Chemistry and Biochemistry and Center for NanoScience, University of Munich (LMU), Butenandtstrasse 5-13 (E), 81377 Munich, Germany.
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  • Thomas Bein

    Corresponding author
    1. Department of Chemistry and Biochemistry and Center for NanoScience, University of Munich (LMU), Butenandtstrasse 5-13 (E), 81377 Munich, Germany
    • Department of Chemistry and Biochemistry and Center for NanoScience, University of Munich (LMU), Butenandtstrasse 5-13 (E), 81377 Munich, Germany.
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Abstract

original image

Different bioactive molecules are released into living cells from lipid-covered mesoporous silica nanoparticles. The release is triggered by light, as the particles feature covalently attached photosensitizers as membrane-opening agents. It is demonstrated that the particles achieve endosomal escape and that they release their cargo into the cytosol.

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