Get access

New Biomimetic Directions in Regenerative Ophthalmology

Authors

  • David W. Green,

    Corresponding author
    1. Queensland Eye Institute, 41, Annerley Road, Brisbane 4001, QLD, Australia, Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane 4072, QLD, Australia
    • Queensland Eye Institute, 41, Annerley Road, Brisbane 4001, QLD, Australia, Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane 4072, QLD, Australia.
    Search for more papers by this author
  • Gregory S. Watson,

    1. School of Pharmacy and Molecular Sciences, James Cook University, Molecular Sciences Building, DB-21, Townsville, QLD, Australia.
    Search for more papers by this author
  • Jolanta Watson,

    1. School of Pharmacy and Molecular Sciences, James Cook University, Molecular Sciences Building, DB-21, Townsville, QLD, Australia.
    Search for more papers by this author
  • Samuel J. K. Abraham

    1. Nichi-In Centre for Regenerative Medicine, Yamanashi University-Faculty of Medicine, Chuo-shi, Japan 409-3898, and C 16 & 17, Vijaya Health Centre Premises, 175, NSK Salai, Vadapalani, Chennai -600 026, Tamil Nadu, India
    Search for more papers by this author

Abstract

One of the most complete and permanent ways of treating many causes of visual impairment and blindness is to replace the entire affected tissue with pre-cultured ocular tissues supported and maintained on biomaterial frameworks. One direction towards enhancing ocular tissue regeneration on biomaterials, in the laboratory is by applying biomimicry. Specifically to engineer biomaterials with important functional elements of the native extracellular matrices, such as topography, that support and organise cells into coherent tissues. Further problems in regenerative ophthalmology can be potentially solved through application of biomimicry. They include, more efficient ways of moving and transplanting cultivated tissues into correct therapeutic locations inside the eye and scar-less, non-destructive healing of surgical incisions and wounds, to repair structural integrity of tissues at the ocular surface. Two examples are given to show this potential for redeveloping an ocular epithelium onto a nanostructured insect wing surface and producing an origami membrane modelled on deployable structures in nature. Efforts to harness natural innovation will eventually provide unique designs and structures that cannot for now be made synthetically, for regeneration of clinically acceptable ocular tissues.

Get access to the full text of this article

Ancillary