Highly Potent Bactericidal Activity of Porous Metal-Organic Frameworks

Authors

  • Wenjuan Zhuang,

    1. Chemistry Department, Texas A&M University, College Station, TX 77843, USA
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  • Daqiang Yuan,

    1. State Key Laboratory of Structure Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, P.R. China, and Chemistry Department, Texas A&M University, College Station, TX, 77843, USA
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  • Jian-Rong Li,

    1. Chemistry Department, Texas A&M University, College Station, TX 77843, USA
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  • Zhiping Luo,

    1. Microscopy and Imaging Center and Materials Science and Engineering Program, Texas A&M University, 2257 TAMU, College Station, TX 77843, USA
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  • Hong-Cai Zhou,

    Corresponding author
    1. Chemistry Department, Texas A&M University, College Station, TX 77843, USA
    • Chemistry Department, Texas A&M University, College Station, TX 77843, USA
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  • Sajid Bashir,

    1. Chemical Biology Research Group, Texas A&M University-Kingsville, MSC 161, Kingsville, TX, 78363 and Advanced Light Source Division, Lawrence Berkeley National Laboratory, USA
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  • Jingbo Liu

    Corresponding author
    1. Chemistry Department, Texas A&M University, College Station, 77843, and Texas A&M University-Kingsville, Kingsville, TX, 78363, Advanced Light Source Division, Lawrence Berkeley National Laboratory, USA
    • Chemistry Department, Texas A&M University, College Station, 77843, and Texas A&M University-Kingsville, Kingsville, TX, 78363, Advanced Light Source Division, Lawrence Berkeley National Laboratory, USA.
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Abstract

Recent outbreaks of bacterial infection leading to human fatalities have been a motivational force for us to develop antibacterial agents with high potency and long-term stability. A novel cobalt (Co) based metal-organic framework (MOF) was tested and shown to be highly effective at inactivating model microorganisms. Gram-negative bacteria, Escherichia coli (strains DH5alpha and XL1-Blue) were selected to determine the antibacterial activities of the Co MOF. In this MOF, the Co serves as a central element and an octa-topic carboxylate ligand, tetrakis [(3,5-dicarboxyphenyl)-oxamethyl] methane (TDM8−) serves as a bridging linker. X-ray crystallographic studies indicate that Co-TDM crystallizes in tetragonal space group Pequation image21m with a porous 3D framework.

The potency of the Co-TDM disinfectant was evaluated using a minimal bactericidal concentration (MBC) benchmark and was determined to be 10–15 ppm within a short incubation time period (<60 min). Compared with previous work using silver nanoparticles and silver-modified TiO2 nano- composites over the same time period, the MBC and effectiveness of Co-TDM are superior. Electron microscopy images indicate that the Co-TDM displayed distinctive grain boundaries and well-developed reticulates. The Co active sites rapidly catalyzed the lipid peroxidation, causing rupture of the bacterial membrane followed by inactivation, with 100% recycling and high persistence (>4 weeks). This MOF-based approach may lead to a new paradigm for MOF applications in diverse biological fields due to their inherent porous structure, tunable surface functional groups, and adjustable metal coordination environments.

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